It's definitely too far to drive from Sequoia to Zion in one day ... and there's no way to avoid Las Vegas. You shouldn't have a problem driving through Vegas in the middle of the day with a trailer. Just be sure to avoid the morning and evening rush hours.
I'd also not recommend driving through Death Valley with a trailer. There's not a lot of services and depending on the time of year it will be very hot.
If you want to make it a two day drive, I'd recommend Valley of Fire just north of Las Vegas for the second night. We did a "don't go more than 5 feet from your car" drive through a couple of years ago and are anxious to go back.
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2009 2720SL
2014 Toyota Sequoia
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